Background: Sepsis is associated with a dysregulated inflammatory response, along with a shift in the redox balance toward the oxidant state. Kecombrang (Etlingera elatior) is proposed to have the ability to suppress inflammation and oxidative stress through the control of caspase-3 and IL-1ß. Objectives: This study aims to investigate the effect of extracts of Kecombrang fruit on caspase-3 and IL-1ß level in Mus musculus sepsis model. Methods: This laboratory experimental study was conducted on a total of 20 Mus musculus which were equally divided into four groups. Group I received lipopolysaccharide (LPS) induction as the control group. Group II received LPS induction and pretreated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for 5 days before induction of LPS. Group III received LPS induction and treated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for 5 days after induction of LPS. Group IV received LPS induction and treated with methanol extract ofKecombrang fruit (4.2 mg/20 gr) at the same time induction of LPS. The measured outcome was the serum concentration of caspase-3 and IL-1. Data were analyzed using ANOVA with p <0.05. Results: Pretreated Kecombrang extracts significantly decrease the serum levels of caspase-3 and IL-1ß (p<0.05). Conclusions: The beneficial effects of the extract of Kecombrang fruit on sepsis are evident from the observations. It can be said that the extract of Kecombrang fruit can be exploited in the treatment of sepsis.