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Identification of potential therapeutic target of niazimicin of Moringa Oleifera L in colon cancer by bioinformatics study
Last modified: 2021-09-20
Abstract
Niazimicin is a active constituen of Moringa oleifera L. This study aims to to find the potential therapeutic targets of niazimicin for colon cancer treatment by using bioinformatic analysis. Some databased were used such as NCBI for a source of genes that involved in colon cancer genes, Swiss Target Prediction as a source information to target genes of niazimicin. Gene ontology profiles, KEGG pathways, protein–protein interaction, drug diseases associations of the potential target genes. A total of 3203 colon cancer genes and 100 predictive target genes of niazimicin were aligned, resulting in 59 genes of matches genes mainly enriched in the neomycin, kanamycin, and gentamicin biosynthesis; apoptosis; central carbon mechanism in cancer; fructose and mannose metabolism; prolactin signalling pathway. The top 5 hub genes GAPDH, EGFR, CASP3, SRC, MAPK1 showed major involvement in colon cancer, suggesting a possible mechanism of niazimicin as a promising agent to the colon cancer drug development.